Quality of life is a multidimensional concept that is explored frequently, in different populations and areas. This paper discusses the quality of life of parents of children with disabilities. Namely, the quality of life is subject to changes due to all the challenges faced by parents, which are especially stressful for parents of children with disabilities. A review of the available literature showed that the quality of life of parents of children with disabilities is generally somewhat lower than that of parents of children with normal development and that it is associated with a number of factors, such as parental stress, social support or coping strategies. The aim of this paper is to systematically present part of the scientific knowledge in this field in the period from 2012 to the present. Changes in the quality of life, but also in many other areas, have recently been linked to the current COVID-19 pandemic, which has also affected parents of children with disabilities. Since the system of rights and services for these parents in Croatia is not sufficiently developed, the findings from this paper can encourage activities to improve it. The service of early intervention is especially emphasized, considering the important role of various forms of social support in the quality of life of parents of children with disabilities. Different methods of social work can be useful for these parents and some of them are suggested in the paper.