In this paper we have studied WISE social enterprises as the employers of people with disabilities in five post-communist countries and closely analyzed five examples of WISE social enterprises employing people with disabilities. We have identified several characteristics in development of WISE social enterprise in analyzed countries. Poland has a high level of decentralization- regarding role of municipalities in organization and governing WISE social enterprise. Slovenia has adopted lex specialis in regulation activities of social entrepreneurship with Social Entrepreneurship Act. WISE social enterprise in Slovenia tend to be small and employ small number of people with disabilities; Slovakia’s development of WISE social enterprise has two characteristics: a) existence of umbrella organization, who has a role to coordinate and promote collaboration of all existing WISE social enterprises in the country and b)possibility of financing social enterprise via tax assignation from income tax; Czech Republic has given WISE social enterprise a dominant role regarding other forms of social enterprise. Croatia has shown a significant delay in development of WISE social enterprise regarding other analyzed post-communist countries. WISE social enterprises in Croatia tend to be small and employ small number of people with disabilities. Nonetheless, we have identified a few common barriers in development of WISE social enterprise in these countries: a) lack of continuous funding sources; b) insufficient level of employee expertise; c) demotivation of persons with disabilities to engage in WISE social enterprise; d) insufficiently public awareness of the importance and values of WISE social enterprise.