Social care centers represent the most important institution in the social work profession in Croatia. The importance is reflected in the number of employed social workers, the roles of social workers and the number of powers within the competence of social workers. Social workers in social care centers are burdened not only with the amount of work, the number of beneficiaries, but also with the emotional pressures of providing daily support to beneficiaries in the most difficult moments and in the most intimate areas of life. Previous knowledge has established that the profession of social work is high-risk for the development of burnout, and consequently for the development of health difficulties. Therefore, the goal of this doctoral research was to examine the presence of different sources of professional stress, burnout syndrome at work and health problems of social workers employed in social care centers in the Republic of Croatia, and to determine the contribution of some demographic and professional characteristics of social workers, different stressors, job satisfaction, stress related to COVID, social support in the work environment and coping strategies in explaining the level of burnout and health difficulties. Three research problems were set, and to verify which procedures descriptive analysis and multivariate analysis (hierarchical regression analysis) were used to explain the level of burnout and health of social workers as criterion variables. The results showed that social workers consider the most common sources of stress related to the social worker's job itself, followed by stressors related to rewards and promotion, then those related to the organizational climate, and finally those related to working conditions. According to the results, social workers most often use active stress coping strategies focused on solving problems, followed by passive strategies focused on emotions and rarely avoiding problems. Social workers report equal levels of self-assessed levels of emotional exhaustion of social workers and self-assessed levels of reduced personal achievement. The hypotheses set in the framework of the other two research problems were not confirmed. The predictive effect of individual variables is different on the three dimensions of burnout, that is, the different predictive effects were determined by analyzing the results of the two questions that examined hypothesis 3. This research is pioneering in the Croatian cause in terms of examining the predictor contribution to combustion of variables that have not been examined in Croatian samples so far. Also, for the first time, the predictive contribution in the explanation of health difficulties was investigated, which laid the foundations for future research on the population of Croatian social workers