Drug addiction has been a burning problem at the global level for many years. In addition to traditional drugs, new, synthetic substances appearing on the market are a growing issue. With an unknown chemical composition, in attractive packages, easily available in stores and at affordable prices, and bypassing legal regulations, they are offered to anyone ready to experiment or recreational drug abuse. Due to their unpredictable action, unknown composition, and the impossibility of their detection on rapid drug tests, they represent a challenge for health workers and other professional associates in the care of intoxicated patients. Pharmacological therapy is effective in the treatment of current symptoms, but for the recovery to last, individual and group therapy and the support of professional services are needed. Therapeutic communities, as an extra-institutional form of treatment, play a key role here due to the way they work and the psychosocial treatments they offer, especially suitable for young people who come for treatment of addiction to these substances. A multidisciplinary team is crucial for the effectiveness of the treatment, through the cooperation of the person who is offered a comprehensive and individualized approach to the problem.