Despite many conventions, documents and domestic legislation that provide protection and protect rights, people with disabilities still face numerous challenges during employment. Prejudices, architectural barriers, poor information on the part of employers and unsuitable workplaces are just some of the challenges they face that make it difficult to enter the labor market. Also, people with disabilities often have their own distorted perceptions and are insufficiently motivated, which can further complicate their integration into the labor market. Employment represents a key role in the social integration of individuals. In the Republic of Croatia, there is a visible increase in the employment of people with disabilities, but this positive progress is still quite slow. The employment quota system is one of the approaches that aims to facilitate the inclusion of people with disabilities in the labor market, but this approach can also bring many negative psychological consequences, such as self-stigmatization of people with disabilities. The aim of this paper is to study and analyze the international and domestic legal frameworks that regulate the employment of persons with disabilities in the Republic of Croatia and to investigate the challenges they face. Examples of good employment practices in other European countries can provide guidance and recommendations for improving domestic practices. Employment of persons with disabilities contributes not only to their personal well-being, but also to the positive development and strengthening of society as a whole.