Mental health is an important component of the lives of all people including persons with disabilities which affects the welfare and everyday functioning to a great extent. Persons with disabilities a group that faces numerous challenges ona daily basis, including social isolation, stigmatization, discrimination and difficult access to all services which makes them degraded compared to the rest of the population without disabilities. Social isolation is often caused by physical barriers that prevent active participation in society while stigma and discrimination further burden mental health. Despite the progress of the legal system and the improvement of the rights of persons with disabilities, the application in practice is still insufficient. Inadequate access to health services is also a challenge as systems are often not adapted to the specific needs of people with disabilities. Prolonged waiting time for therapy and lack of specialized services lead to the deterioration of mental health. Financial insecurity and unemployment, related to disability, further worsen the mental state thus creating a vicious circle of stress and poverty. A key element in the preservation and well-being of the mental health of persons with disabilities lies in promoting and increasing inclusion. Social programs that promote the participation of persons with disabilities in social activities can help reduce social isolation and stigmatization. Furthermore, continuous education of persons with disabilities, their families, as well as the wider community is essential for recognizing early signs of mental problems and enabling timely access to the necessary services. Ultimately, policies that address social determinants of mental health need to be developed and implemented, including combating stigma, ensuring equal employment opportunities and improving access to education and health services. In addition, it is important to establish international and intersectoral collaboration, which would enable a better coordination of resources and experts on a global scale with the aim of providing support in preserving the mental health of persons with disabilities. Through a targeted and coordinated approach that includes health, social care, education and employment, the necessary support to preserve the mental health of persons with disabilities and the realization of their full potential can be ensured.