Hypodontia is a congenital anomaly which implies the lack of one or more teeth buds in the deciduous or permanent dentation, excluding wisdom teeth, and it is conditioned by circumstantial and genetic factors. 7 % of the European population is usually affected by a mild condition of hypodontia, lacking one or two teeth. Patients with hypodontia mostly complain about aesthetics and function of missing teeth like the shift of adjacent teeth towards vacant areas and the eruption of antagonists. Prior to initiating orthodontic therapy, it is necessary to carry out an extraoral and intraoral analysis as well as an analysis of the cephalogram to determine which therapy is best for the patient i.e., which is the best way of establishing adequate function and patient profile. The therapy used might be entirely orthodontic, through which the vacant area is filled by mesialization or distalization of adjacent teeth. Another option is to take an interdisciplinary approach combining efforts of an orthodontist, a prosthetist and an oral surgeon – which implies setting apart adjacent teeth in the course of orthodontic therapy thus making room for the missing tooth. That tooth is then compensated by a dental bridge which can be conventional, adhesive or a cantilever dental bridge or by placing a dental implant and forming a dental crown on top of the implant.