Since the first successful laser application in dentistry in 1965 indications for the use of different types of lasers are all wider (1). One of the areas the endodontic treatment of primary teeth is successfully applied, with 980 nm wavelength diode lasers suitable for the pulpotomy procedure (2). Although some studies show the benefits of laser compared to the conventional method of clinical studies are lacking. The material for a definitive filling of endodontically treated primary teeth can also affect the outcome of the therapy. Therefore, the purpose of this observation was to compare the clinical use of the pulpotomy laser with the classic vital pulpotomy method and the influence of the material for definitive filling for the final outcome of the procedure. A clinical study was conducted over a period of 2 years, involving 120 patients at the age of 5-8 years at the Department of Pediatric Dentistry at the Faculty of Dental Medicine of the University of Zagreb. Patients were divided by randomized selection into two groups. In the first group there was 60 examinees where the vital pulpotomy method was used with a carbid drill or an excavatron in local anesthesia. In the second group devitalization was carried out using a 980 nm wavelength diode laser in local anesthesia. Biodent was used in both groups to cover the root portion of the pulp. Each group was randomly divided into two subgroups according to the type of material for the final filling (composite material and glass ionomer cement). Checkups were conducted after 6 months, 12 months and 24 months from the first procedure. Before the preliminary procedure and during the control examinations, clinical examination and X-ray analysis of treated teeth was performed. Clinical examinationl included: intraoral and extraoral visual examination, percussion and palpation. The X-ray analysis was conducted to show the continuity of the hard lamina and the existence of periapical lesions in the area involving the support of the treated tooth, the surrounding tissue of the adjacent two teeth, and the condition of the permanent tooth embryo. The planned research period was 2 years. Criteria for the success of the treatment were: a tooth without any symptoms without color change, without periapical changes, without loss of periodontal attachment, neat radiological findings and functions in occlusion to natural exfoliation. Filling quality were evaluated by USPHS (United States Public Health Service) criteria. Statistical data processing were done in choleration to the pulpotomy process with the treatment outcome and the kind of permanent fill material with the treatment outcome. Both groups controled the condition of soft tissue endodontically treated primary teeth within two years.