The direct oral anticoagulant medicaments (later found as DOAC`s) are a relatively novel concept on the current medical market. Their administration is intended for both treatment, and prevention of certain cardiovascular and cerebrovascular diseases. As of now, there are four prevalent medicaments: dabigatran (Pradaxa®), rivaroxaban (Xarelto®), apixaban (Eliquis®), and edoxaban (Lixiana®). Dabigatran is utilized as a direct inhibitor of thrombin, while the rest of the listed substances are applied as FXa inhibitors. At this particular moment in time there are no specific tests that would precisely define the coagulation status with patients who actively use these drugs, unlike with patients that were prescribed a vitamin K antagonists. Due to their improved properties and ease of use, DOAC’s are being prescribed more and more. We currently have relatively little data on these drugs in dental practice and this often leads to ambiguities in the treatment of these patients. The consensus in the literature is that DOAC therapy is not discontinued in most cases, as discontinuation of therapy increases the risk of thromboembolic events and is of greater importance in relation to bleeding, which is usually resolved by local hemostasis measures. With patients who are in need of a more comprehensive medical procedure, or with patients who have underlying conditions that may lead to severe hemorrhaging, the therapy may be terminated after consulting with the supervising physician.