Liver cirrhosis is a pathological process in the liver parenchyma that occurs due to the necrosis of hepatocytes. It is characterized by the formation of non-functional fibrous tissue around necrotic hepatocytes and their replacement by regenerative nodules. There are numerous causes of liver cirrhosis, but regardless of their etiology, over time, similar damage to the liver tissue occurs, so the clinical manifestation of the terminal stage of chronic liver diseases has similar symptoms in most patients. In the initial stages of the disease, the organizational structure of the liver is not yet completely damaged, so clinical symptoms that would point to pathological changes are almost non-existent or mild and non-specific. Such a state is called the compensated stage of the disease since all liver functions are at least partially preserved. It is only in the decompensation phase that severe clinical symptoms begin to appear, which are often a manifestation of numerous systemic disorders arising as complications of the chronic liver disease itself. In addition to the dramatic clinical picture, changes in the patient's laboratory parameters are also evident, which often indicate pancytopenia, prolonged blood clotting time, as well as elevated levels of bilirubin and liver enzymes in the patient's serum, while liver biopsy makes the final diagnosis of cirrhosis. Dental treatment of a patient in the terminal stages of the disease requires great caution, and in order to stop the frequently extensive bleeding, it is necessary to carry out additional measures to achieve local hemostasis. It is also important to protect immunosuppressed patients from complications of the primary disease caused by iatrogenic bacterial infections, but also to protect the entire medical team from potential viral infections (hepatitis B or C).