A new coronavirus appeared in China at the end of 2019, which lead to its name SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2). It was a new strain of the coronavirus that was not detected in humans in the past and the illness caused by the aforementioned virus is referred to as COVID-19. COVID-19 pandemic had a significant influence on dental care. The closure of dental practices rendered high-quality medical treatment of dental patients impossible. There was a significant increase in the number of prescriptions issued by practitioners of dental medicine. Using medications without proper indications could lead to unwanted development of microbial resistance and decrease in therapeutical effectiveness caused by interactions with other medications. The purpose of this paper is to present a statistical overview of the consumption of medications issued by the dental practitioners in the Republic of Croatia during the period from 2019 until 2021. The data used in this paper was acquired with the help of the Croatian Health Insurance Fund (HZZO – Hrvatski zavod za zdravstveno osiguranje). According to the research, the most commonly issued prescriptions were those for antibiotics. Amoxicillin with clavulanic acid, a broad-spectrum antibacterial medication, was the one that was prescribed more often than any other medication. Medications that follow include nonsteroidal anti-inflammatory drugs, out of which ibuprofen was the most prevalent. There was also a noted increase in issuing antiseptics, while the antifungal medicines showed a decline according to the number of issued prescriptions. The consequences that had an effect on the entire healthcare system in the Republic of Croatia during the pandemic should serve as an encouragement for everyone working in dental medicine to advise responsible use of all types of medications.