Growth factors released from platelets during the healing play an important role in the healing of both soft and hard tissues. This fact encouraged the development of thrombocyte preparations in various protocols with the aim of stimulating and accelerating the healing. Thrombocyte enriched plasma is the first generation of blood derivatives to find its application in oral surgery. Due to the more complex preparation and the intensive release of growth factors and other proteins in the first few hours after preparation, caused by the formation of rigid fibrin mesh, it is now mainly replaced by a new generation of thrombocyte preparations – thrombocyteenriched fibrin. Thrombocyte­enriched fibrin is characterized by the formation of a flexible fibrin mesh that allows gradual and longer release of the growth factors, during the healing, and a simple preparation procedure. Membranes and cylinders can be produced by new methods of preparation of thrombocyte­enriched fibrin, which comes in the form of a gel and a liquid, allowing a wide range of application in oral surgery. In order to overcome the problem of insufficient bone quantity and bone defects caused by oral surgery, bone replacement materials are being developed. Apart from the long­standing gold standard – autogenic transplant, the development of allogeneic, xenogeneic, and alloplastic bone replacement materials enabled their wide application and availability. Autogenous transplants are the only ones that have the characteristic of osteogenesis, but some of the advantages of application of the other bone replacement materials are availability in almost unlimited quantities and possibility of the performing of operations without a second, donor, operating field. Due to the lack of a standardized protocol and controlled randomized clinical trials, the consensus of which material is the most effective and for which indication is not reached. Bone replacement materials and thrombocyte preparations are often used in combination to achieve optimal results in a number of oral surgery procedures such as alveolar preservations, alveolar reef augmentation, apicoectomy, cystectomy, jaw osteonecrosis treatment and raising of the bottom of maxillary sinus, and represent a significant step forward in the treatment of numerous conditions, often allowing faster post­operative recovery and sometimes reducing the invasiveness of some interventions and post­operative complications.