Back in the 1920s, science began to question the connection between invasive oral surgery and infective endocarditis, so the first guidelines in which the performance of oral surgery had to be adapted to patients at risk of infective endocarditis were published way back in 1955. More than half a century ago, the guidelines for antibiotic prophylaxis of infective endocarditis were adapted to new knowledge, and the international associations of experts have found precisely in these pioneering guidelines the reputation and incentive to compile guidelines for the performance of oral surgical procedures in other groups of medically compromised patients. Over time, there was a need for an increasing number of guidelines that were not available for other groups of at-risk patients, so, as the medical anamnesis of patients in oral surgery clinics lengthened and the prevalence of various medical conditions changed, guidelines for certain medically compromised groups of patients were published and provided a useful diagnostic tool for oral surgeons worldwide. In modern clinical practice, oral surgeons have at their disposal many guidelines drawn up by different bodies of experts and at different global levels. Moreover, they are digitally available to any interested individual. Today, clinicians have the opportunity to be guided in clinical dilemmas by the abundance of available guidelines adapted and compiled for the same group of medically compromised patients. The difficulty that modern oral surgeons encounter is the difficulty of filtering good from better professional advice. Therefore, it is recommended to follow guidelines that are guided by evidence-based medicine rather than one's clinical experience.