The term “acne-like eruptions” encompasses a variety of skin conditions resembling acne vulgaris. While both acne-like dermatoses and true acne are frequently observed in clinical settings, differentiating between the two might be challenging. Similar to acne, the lesions of acne-like eruptions may exhibit papules, pustules, nodules, and cysts. However, contrary to acne, comedones are uncommon but may still be observed in certain types of acne-like eruptions. Moreover, acne-like eruptions can be differentiated from acne based on their sudden onset, the propensity to occur across all age groups, the monomorphic appearance of lesions, and the distributions extending outside the seborrheic regions. The development of acne-like eruptions cannot be attributed to a single underlying mechanism; nevertheless, various factors such as patient age, infections, occupation, habits, cosmetics, and medications may be involved. The observed lesions may not respond to standard acne therapy, necessitating that treatment strategies are tailored in accordance with the identified causative agents. The following review aims to outline distinct entities of acne-like eruptions and present features that set them apart from true acne. Acne-like eruptions in the adult population, infectious diseases resembling acne, and acne-like eruptions resulting from exposure to chemical and physical agents are addressed in this paper. An understanding of the clinical presentation, pathophysiology, and epidemiology of this group of dermatoses is pivotal for a precise diagnosis and provision of appropriate care.