Plasma is a partially or fully ionized gas composed of a mixture of numerous active components: ions, photons, free electrons, radicals, and various other charged and neutral particles. Cold atmospheric plasma (CAP) is a type of plasma suitable for clinical applications because it is generated at atmospheric pressure and temperatures below 40°C. It can be generated by applying a specific type of energy to a gas or a combination of gases such as argon, helium, and ambient air. There are several different devices that generate plasma, with dielectric barrier discharge (DBD) devices and plasma jet devices being most commonly used for medical purposes. Plasma has found wide application range in the field of biomedical sciences, including dentistry. This study emphasizes the potential of plasma in healing osteonecrotic lesions. Osteonecrosis of the jaw is a pathological condition characterized by damage and progressive necrosis of jawbone tissue. It is categorized into osteoradionecrosis, medication-related, trauma-induced, non-traumatic, and spontaneous osteonecrosis. The main clinical indicator of all types of osteonecrosis is exposed bone tissue that does not heal over an extended period of time. Based on the clinical presentation and radiological findings, different stages of disease can be identified, which then serve as guidelines for selecting the appropriate therapy. CAP represents one of the more recent therapeutic approaches for treating osteonecrosis of the jaw. It is used alongside conventional therapy to accelerate the healing of osteonecrotic lesions, primarily due to its antiseptic properties that establish a sterile environment in the affected area. It is also thought to directly stimulate the healing and regeneration of osteonecrosis-affected tissues by promoting the proliferation and migration of key wound-related cells. Although it is a relatively understudied therapeutic method, it has shown very promising results in the treatment of osteonecrotic lesions, with no recorded negative effects on healthy tissues so far.