The increasingly frequent prescription of antibiotics over the last ten years has started a debate in numerous scientific circles about revising antibiotic prophylaxis guidelines in dental medicine, both in medically compromised as in healthy patients. The ever-increasing prescription of antibiotics was highly affected by the COVID-19 coronavirus pandemic. Such situation has contributed to the higher bacteria resistance to antibiotics, increasing the mortality rate of patients suffering from systemic infection or sepsis caused by multi resistant pathogens. In 2021, the American Heart Association (AHA) published a revision of the antibiotic prophylaxis guidelines for infective endocarditis. The previous revision of the guidelines was in 2007. The new, revised guidelines introduce numerous changes in the choice of antibiotics, replacing certain antibiotics due to excessive complications or excessive resistance. Likewise, when placing dental implants, many Doctors of Dental Medicine prescribe antibiotic supportive therapy to prevent unwanted complications. This situation has prompted numerous scientists to publish scientific papers, review articles, as well as conduct meta-analyses in order to disprove the theory of unwanted complications and advise Doctors of Dental Medicine in which situations, which patients and in which dosage it is necessary to prescribe antibiotic prophylaxis in dental implant surgery in order to prevent the further growing trend of prescribing antibiotics.