Head and neck cancers, which are the seventh most common cancers globally, are often asymptomatic in their early stages, leading to late detection and treatment. In cases of advanced cancer, radical surgical procedures and chemoradiotherapy can significantly affect swallowing, speech functions and facial aesthetics. In this case report, the patient was diagnosed with oropharyngeal carcinoma classified as T3N0M0. Following the primary disease and radical surgical procedures, including a commando operation and reconstruction using an anterolateral thigh (ALT) flap, the patient underwent complex implant – prosthetic therapy. Before radiotherapy, teeth in the lower jaw were extracted due to poor prognosis, while a molar in the upper jaw was preserved for future prosthetic retention. A CBCT scan revealed sufficient bone for implant placement in the lower jaw, allowing the insertion of three Zimmer Biomet Trabecular Metal implants. In the upper jaw, due to the presence of the molar, a subtotal denture was made. Following successful osseointegration of the implants and placement of gingiva formers, the prosthetic phase commenced, which included the creation and fitting of new dentures. These dentures significantly improved patient’s quality of life until the recurrence of the primary disease four and a half years later. This case highlights the importance of a multidisciplinary approach and the integration of surgical and prosthetic methods in rehabilitating patients after radical oncological procedures, as well as the need for therapy adjustment.