Corticosteroids are steroid molecules that belong to the group of hormones produced by the adrenal glands. This group of hormones includes mineralocorticoids, glucocorticoids, and adrenal androgens. Corticosteroid medications are synthetic forms of natural corticosteroids, designed to enhance certain pharmacological effects while simultaneously suppressing others. This is particularly true for glucocorticoids, which are often used in medicine and dental medicine due to their anti-inflammatory and immunosuppressive properties. Despite their many beneficial properties, the use of glucocorticoids is limited due to their numerous side effects, such as suppression of adrenal gland function, hyperglycemia, diabetes, osteoporosis, and neurological, gastrointestinal, muscular, cardiovascular, and dermatological disorders. In dental medicine, corticosteroids are used to reduce pain and inflammation and to treat various oral pathological conditions. The side effects of corticosteroid use in the oral cavity can be numerous and include oral candidiasis, mucosal atrophy, systemic absorption, pain at the application site, and others.