Considering that the new studies are showing that the expression of CD44 in tumors has a prognostic value, the purpose of this research was to immunohistochemically determine expression of CD44 in glioblastoma, and to question its correlation with the density of newly – created blood weasels and survival of the patient. Research was conducted on fifty – five patients with glioblastoma; 26 women (47,3%) and 29 men (52,7%) of average year 62,58 (from 47 do 77). Primary antibody on CD44 (sparse 1:50) and primary antibody on endoglin (CD105) (sparse 1:250) were used. Immunohistocemical analysis was performed with LSAB method on DAKO TechMate TM automatized machine with the use of streptovidin immunoperoxidation MSIP protocol. The results of the analysis were semi – quantitatively shown, and the density of the newly – created blood weasels (MVD) was measured in the most active area of neovascularization of tumor. Statistic analysis of the results was conducted according to the age of patient, length of survival, CD44, MVD/CD105 and Karnofsky Score. The average Karnofsky Score of the patient was 75, 45%, and the average survival of the patient were 183, 82 days. The results of average CD44 was 64, 91 (from 40, 00 to 90, 00), and the average MVD/CD105 – 15, 64 (from 3, 67 to 52, 33). Statistic analysis determined negative correlation between CD44 and the survival (P=0, 023) (bigger expression of CD44 was correlated with the shorter survival), and also positive correlation between Karnofsky Score and the survival (P=0, 018) (bigger Karnofsky Score was correlated with longer survival). The significant individual predictors for longer survival were lower expression of CD44 (P=0, 004), higher Karnofsky Score (P=0, 045), and female gender (P=0, 017). The given results could show the role of CD44 in a progression and tumor neovascularization of glioblastoma, and on its prognostic value, which could be eventually used in the development of specific molecular therapy.