The growth and development of the craniofacial skeleton is based on the movement and surface transformation of the bones, and it lasts from birth to adulthood. The development of the maxilla ends earlier, while the complete development of the mandible may take up to 21 years, which points to the fact that the final occlusion is reached at an adult age. Occlusal problems can occur in three planes, sagittal, transverse, and frontal. Misalignment can occur due to genetics, premature tooth loss, but also because of bad habits such as mouth breathing, thumb sucking or immature swallowing. Malocclusion can be diagnosed early today, enabling early therapy. Early orthodontic treatment or interceptive orthodontics, by using certain methods and appliances, has the purpose of removing conditions that can cause malocclusion or prevent progression of an existing one. Methods used are selective grinding, serial tooth extraction, and myofunctional exercises. Myofunctional exercises can be used as therapy by itself also they are often used in combination with an appliance. Appliances used are spatula, inclined planes, vestibular plates, lip bumpers and trainers. Despite numerous methods and appliances, we can not say which therapeutic procedure is most effective. Each patient should be treated individually, which is also the best therapy.