Dental implants are becoming increasingly prevalent among patients in restoring missing teeth. Although success rates are high at 95-97% in healthy patients, implantologists continue to experience some failure in patients undergoing prescribed treatment. Prophylactic antibiotics are believed to decrease the failure rate if given prior to inserting implants. To provide evidence in support of the hypothesis that there are no significant differences in early implant failure rates if prophylactic antibiotics are (not) given, an electronic search of MEDLINE, PUBMED and the Cochrane data bases was carried out for the period prior to 1 February 2018. Only publications in English were included. Only randomised control trials, prospective cohort studies and retrospective studies on humans were selected. The inclusion criteria included patients who needed dental implant therapy. The exclusion criteria included all patients undergoingcertain treatments such as immunosupresive therapy, chemotherapy, poorly controlled diabetes, pregnancy, antibiotic therapy, those at risk of infective endocarditis, or having a history of bisphosphonates or underoing radiotherapy to the head and neck region. The search results identified various types of studies (randomizied controlled trials, retrospective, and prospective studies). Studies were assessed for methodological quality of the analysis, limitations and potential bias. The analysis was qualitative due to variations in the types of studies. This review found no difference in implant failure between individuals who received implant therapy while taking prophylactic antibiotics compared to patients who received implant therapy while not undergoing prophylactic implant therapy. A well conducted clinical randomised study is necessary to test the effect of prophylactic antibiotics in implant therapy. Gvien that the studies examined were so varied in their design and outcomes, it was not possible to perform a meta-analysis. All studies have been assessed individually and qualitatively.