Plants and various products of natural origin have traditionally been used for the treatment of various diseases in all parts of the world for centuries, while in developing countries even today 80% of the population is dependent on medical plants. The history of medicines and the knowledge of their use are a part of the cultural history of mankind. Contemporary pharmacology begins with the knowledge and use of plant, animal and inorganic (mineral) raw materials. The increasing resistance of pathogens and the increased incidence of side effects due to excessive use of conventional drugs have prompted researchers to begin searching for new sources of medicines, both chemically synthesized and those of natural origin. In dental medicine, the most famous plants, herbal or animal origin products used are neem, turmeric, propolis, aloe vera, Camellia sinensis, various essential and vegetable oils, although even lesser known plants that show promising health features such as Salvadora persica, Ocimum sanctum, Morinda citrifolia and many others are being brought into focus more and more. Because of their positive therapeutic effects (antibacterial, antiviral, antifungal, antioxidant, anti-cancer, anti-inflammatory, immunomodulatory) and various mechanisms of action, they could find their role as auxiliary and perhaps the main agents in the treatment of various tooth, periodontal and mucous diseases and conditions, as well as in various branches of dental medicine such as endodontics, orthodontics and oral surgery. So far, mainly in in vitro studies, they have shown remarkable properties comparable to gold standards such as chlorhexidine and sodium hypochlorite, and with conventional drugs. Although natural remedies are generally considered safe and with fewer side effects, many clinical studies are needed to determine their safety and possible toxicity so that they could come to life in day-to-day practice.