Since the early '80s dental implants have provided a new dimension to all areas of dental medicine and have provided a new system of rehabilitation of the patient's existing oral cavity condition. Level of success of the implat therapy is very high, but the complications related to dental implants are not insignificant. Today implantology is developing in a way that enables the procedures to be minimally invasive, fast, and precise, with the technology and the operative procedures themselves being in line with the modern pursuits. Osseointegration is a mechanism of creating a direct connection between the bone in which the implant is implanted and the implant, and was first described by Brånemark, thus advancing the entire dental science The outcome of successful implant therapy depends on many factors involving the surgical and prosthetic phase of therapy. At the same time, if the therapist is not familiar with the patient's medical history and health condition, the ultimate success of implant therapy may be absent. In fact, the impact of system diseases on oseointegration and the success of implantation is an extremelly important factor in the process of implant therapy both for the patient and the dentist. In that regard, obtaining a detailed and accurate medical and dental anamnesis reduces the number of diseases that enter a differential diagnosis and helps the therapist to get acquinted to the patient's health condition before the actual placing of the implant. Premature loss of an implant or loss during the healing period, is an outcome of an unsatisfactory oseointegration and depends on many factors. The goal of every implantoprosthetic rehabilitation should be to accomplish well-being in a sense of the patient's life quality in relation to the risks brought by the implants, and every system disease can be a potential risk factor if the therapist isn't acquinted to it's impact on the human organism.