Odontogenic inflammation is an inflammatory process in the body related to teeth. The most common causes of odontogenic infections are connected with invasion of bacteria through an infected tooth pulp, periodontal tissue or other surrounding structures. The aerobic bacteria, which is oxygen dependent, is prevalent in the early stages of odontogenic infection while in the later stages the microbial flora is mostly consisted of anaerobes which are not oxygen dependent bacteria. Odontogenic inflammation can be divided into an acute phase, when edema and cellulitis occur followed by pain, and a chronic phase which is characterised by abscess forming, namely a limited purulent infection. Spreading of odontogenic inflamamtion depends on the surrounding muscles and fascia and for that reason the majority of infections appear on specific places of the head and neck. If the odontogenic infection is not treated it could lead to severe complications out of which some are even life-threatening. The therapy of odontogenic inflamamation consists of removing the source of the inflammation (endodontic treatment or tooth extracion), eliminating pus, achieving drainage (opening the tooth, tooth extraction, intraoral and extraoral incision) and antibiotic therapy. Empirical antibiotic of choice in managing odontogenic inflammation is penicillin, i.e. amoxicillin with clavulanic acid. Metronidazole can be added, depending on the severity of the infection, alongside aforementioned penicillin. If the patient is allergic to penicillin, clindamicin is prescribed.