Objectives: Determine the function ability of stomatognatic system in patients with multiple sclerosis (MS); Determine the symptoms and signs occurrence of tempomandibular dysfunction (TMD); Determine the form and intensity of clinically determined stomatognatic system disfunction; Evaluate the TMD intensity and MS course connection. Patients and Methods: 50 MS patients took part in the research from the Primorsko-goranska and Istra region that have been treated during their illness at the Neurology clinic of the Clinical centre and Medical school at the University of Rijeka, in Rijeka. The research group was formed out of 14 men and 36 women aged between 20 and 75. All the patients met the diagnostic criteria for clinically and laboratory followed MS determination according to C.M. Poser. At the stomatognatic system function analysis we have used originally made anamnesis and clinical questionnaire. Anamnesis questionnaire comprised of specific questions on subjective pain experience in the orofacial region, appearance of sounds in temporomandibular joints (TMJ), function limitations and disturbance and other issues referring to possible aetiology of TMD. Clinical research included occlusion, jaw joints and masticating muscles state evaluation, as well as stomatognatic system function activity. Results: TMD symptoms were statistically significantly present in MS patients than in the control group. Occlusion variables among the groups under research showed statistical insignificance in the teeth count (MS 24,80+/-3,76; control group26,48+/-2,65; p<.05). Average amounts of ali limited movements were significantly fewer in MS patients related to the control (p<.05). The most present diagnosis according to RDC/TMD protocol were: myofacial pain (MS 32%; 2% control group; p<.05), disc shift to the right (12% at MS patients; 6% at control; p>.05), disk shift to the left (12% at MS patients, 4% at control; p>.05), and disorders of the IIl group (arthralgiae, arthritis, arthrosis) (14% MS patients to the right (p=.023) and 16% to the left (p=.012) and at 0% control; p<.05). Subjects psychological status has shown that 42% of Ms patients had moderate and elevated depression, 52% moderate and elevated results of non-specific physical symptoms and 38% chronicle pain of the degree III and IV. Related to the control group where ali the results have been significantly lower, there was statisticaliy significant difference in ali the variables. Conclusions: This research results showed a great occurrence of TMD symptoms in MS patients related to the control group. The most common symptom of TMD is pain that occurs more often and more intensely than in the control group. The amount of mandibular movement limitations lead to the diminished functional capability of stomatognatic system in MS patients. Muscular dysfunction are the most common form of TMD in MS patients and are significantly more frequent than in the control group. This research confirmed the thesis how MS can be considered as the predisposing factor in tempomandibular dysfunction making.