Aim: The aim of the research was to analyze the incidence and results of treatment of Guillain-Barré syndrome in General Hospital Dubrovnik in a 4-year period (01.01.2016.-31.12.2019.). Objectives and Methods: By searching the hospital information system of the General Hospital Dubrovnik in the mentioned period, 21 patients with diagnosed Guillain-Barré syndrome were found. Patients suffering from chronic inflammatory demyelinating polyneuropathy and other similar neurological diseases were excluded. The following parameters were observed in each patient: age, gender, date of admission to hospital, variant of Guillain-Barré syndrome, existence of previous respiratory and gastrointestinal infection, presence of anti-ganglioside antibodies, duration of hospitalization, use of mechanical ventilation, and degree of recovery. The results of the population census of the Republic of Croatia in 2021 were used as a source of date on the population of Dubrovnik-Neretva County. Statistical data processing was performed using the statistical package IBM SPSS Statistics for Windows, version 23.0 (IBM, Armonk, NY). Results: From the presented results, it can be seen that the incidence of Guillain-Barré syndrome in General Hospital Dubrovnik is higher than the average values at the level of the Republic of Croatia and the Western world (3.67 per 100,000 inhabitants). The largest share of patients are people aged 61 to 80 years old. The disease predominantly affects the male gender, and the most common variant is acute inflammatory demyelinating polyradiculoneuropathy. Guillain-Barré syndrome is most often diagnosed during the summer. The average hospitalization was 15 days. No deaths were reported, and the vast majority of patients recovered well. Conclusion: The initial hypothesis, according to which the incidence of GBS in OB Dubrovnik is not higher compared to the rest of the Republic of Croatia and the world population, was not supported.