Chronic liver diseases, including liver cirrhosis, as their last stage, are a major public health problem in the world, despite the fact that most of them can be treated and prevented. Liver cirrhosis is defined by the presence of certain anatomic abnormalities of liver structure. Cirrhosis can arise from many diverse causes, and thats why she is often difficult to diagnose. The most common cause of cirrhosis in Western countries is alcoholic liver disease, followed by chronic viral hepatitis, medications,vascular, autoimmune and metabolic disorders. The clinical manifestations are similar, regardless of origin, and are dominated by consequences of portal hypertension such as ascites, esophageal varices, and splenomegaly. Other complications related to cirrhosis are: spontaneous bacterial peritonitis, portal encephalopathy, infection, hepatorenal syndrome, hepatocellular carcinoma etc. Treatment of liver cirrhosis consists of a series of nonpharmacological, pharmacological and therapeutic procedures. Paracentesis is performed for therapeutic purposes, and in the treatment of the terminal phase of the disease, the only satisfactory method is liver transplantation. The aim was to define liver cirrhosis and describe anatomy, physiology and liver pathophysiology. The etiological factors of the disease and the frequency of their occurrence are also defined in the paper. Clinical picture, disease diagnosis and treatment are described. The most important part of the paper include nurses diagnosis, interventions, education and preventive activities of nurses. The paper also mentions the issues of labeling patients suffering from cirrhosis.