Autism spectrum disorder is a neurodevelopmental disorder whose symptoms begin to appear in early childhood (most often in the first three years of a child’s life). The incidence of this disorder is increasing and it is no longer uncommon to encounter a child or adult with some form of autism spectrum disorder in their own environment. Despite this, autism is still a significant unknown to most people and a great challenge to anyone working with children or adults with this disorder. Their specifics in communication and interaction often make it difficult to interact with them, learn, work, and other activities. Autism spectrum disorder involves different forms of autism as well as differences in providing the level of support they need to function. Despite the large differences within the spectrum, there are some characteristics that connect them. Difficulties in communication (verbal and nonverbal), socialization (reduced desire to contact people, inappropriate relationships with others, lack of understanding of the way people cooperate with each other, communicate), and the existence of some repetitive actions or narrowed and specific interests or fixations are specific symptoms present. These symptoms are more or less present in all children and adults with autism spectrum disorder. These characteristics significantly affect the daily functioning of people and it is important to be aware of them in contact with each other, and the environment must know them and adapt to help them. In her daily work, the nurse often encounters children and adults with various difficulties or mental illnesses. In addition to education, acquired knowledge and skills related to certain conditions and diseases can facilitate the process of examination, hospitalization or rehabilitation of a child who is afraid, does not tolerate changes, is afraid of examination and the like. Knowledge, experience and acquired skills on how to approach a child to a nurse provide security and training, and can provide better support to parents and the child during their stay in the health facility.