In December 2019., severe acute respiratory syndrome coronavirus 2, SARS-CoV- 2, appeared in the Chinese city of Wuhan, which causes coronavirus disease 2019, COVID-19. Healthcare professionals represent a high-risk group for SARS-CoV-2 infection as they come into direct contact with the infected patients, and the physical and mental health of healthcare professionals is significantly at risk because they work under unprecedented pressure and are more vulnerable to the harmful effects of the disease. Prevalence of anxiety, depression, insomnia, sleep disorders, burnout, fear, post-traumatic stress disorder, psychological stress increased among healthcare professionals during the COVID-19 pandemic. Burnout is usually considered an individual's response to the long-term stress associated with work, which affects job satisfaction and often affects productivity, performance, coping and well-being of healthcare professionals. Nurse burnout was recognized as an epidemic of health care even before the pandemic, and the pandemic has further exacerbated the situation, while research suggests a higher burnout rate than the pre-pandemic period. The aim of this study is to determine the presence and prevalence of nurse burnout syndrome during the COVID-19 pandemic and whether nurses are more exposed to burnout syndrome during the pandemic compared to the period before the pandemic. A crosssectional survey was conducted during November 2020. on a sample of 100 nurses using a questionnaire available online. The questionnaire consists of a part that examines socio-demographic data and a Copenhagen Burnout Inventory tool for assessing burnout syndrome that has been modified for the purpose of this research. The results were processed by the IBM SPSS 22 computer program. The results indicate the presence of nurse burnout syndrome during the pandemic as well as a higher degree of burnout during the pandemic. The organizational and logistical problems that arise during each crisis, especially during the COVID-19 pandemic, point to shortcomings in the organization of the healthcare system that need to be improved in order to reduce the occurrence and intensity of nurse burnout syndrome that provide direct and necessary care to the patients.