Rheumatic diseases, due to their complexity, required a revolution in healthcare, new discoveries and new knowledge in order to make diagnostics and treatment as efficient as possible. Ankylosing spondylitis was once considered only a sub-type of an already discovered disease. With modern diagnostics, doctors and diagnosticians have determined how it differs from other diseases, which helped in its detection and treatment. Although there is no complete cure, the disease is successfully controlled with developed therapies. While there is a biological therapy that has the maximum effect of suppressing the symptoms of the disease, kinesitherapy is still number one in maintaining a person's functionality. Successful rehabilitation requires the work of not only the medical team but also the patient, his education and motivation greatly affect their complete state of health. An interdisciplinary approach to patients has been shown to be the most successful approach. Long-term and short-term goals are now addressed with the help of a complete medical team. By breaking down the difficulties, treatment efficiency and patient satisfaction is at the highest possible level.