In today's healthcare system, communication between patients and healthcare staff is essential for providing quality healthcare. The aim of this research was to investigate the satisfaction of patients with communication with health care personnel in different levels of health care. Specific objectives included determining patients' preferred mode of communication, investigating patient satisfaction with different modes of communication, and determining the frequency and reasons for difficulties in understanding medical information. Respondents and methods: 374 patients from all counties of the Republic of Croatia who voluntarily agreed to fill out the Questionnaire on health personnel and patients participated in the research. Results: 374 respondents from the entire Republic of Croatia participated in the research. Most respondents were female (85.03%), with the largest share in the age group of 31 to 40 years (36.63%). Most respondents have a secondary vocational education (47.06%). The analysis included communication with health personnel in primary, secondary and tertiary health care. Respondents showed the greatest satisfaction with communication in primary health care, especially via electronic mail. Respondents also expressed a positive attitude towards the importance of communication between healthcare staff and patients. No significant association was observed between satisfaction with communication and trust in the medical staff and experiencing difficulties in understanding medical information with regard to the sex of the respondents. However, a significant correlation was observed between the preference for electronic forms of communication and the age group of the respondents (p = 0.0103). Conclusion: The research showed patient satisfaction with communication with staff and the need to improve communication skills and integrate digital tools to improve the experience and provide better quality care.