Global changes in twenty first century created strong need for environment protection and nature protection. Although these global changes altered significant portion of environment in the world, the largest continental and the most sparsely populated region of Croatia, Lika, was mostly spared of the negative impacts. Today Lika is known as region of exceptional landscape beauty, unique relief and climate features, diversity of flora and fauna and many protected areas (i.e. National Park Plitvička jezera). Aim of this paper is to analyze and systematize most important data about protected areas in Lika. This includes all data of national and international categories of nature protection, data about target species in the area of ecological network Natura 2000, global and regional conservation status of species and degree of conservation of habitat types important for conservation of species. The study was made using Bioportal (Online Information system of nature protection) and using data available in the IUCN Red Lists (global conservation status of species) and valid Red lists of the Republic of Croatia (regional conservation status). Results of research show that Lika is region with highest proportion of protected areas in Croatia (50 %), with many areas protected on the national (28 protected areas in 7 national categories) and international level (Ecological network Natura 2000 - 46 areas, UNESCO World heritage list-2, MaB-1). Also, Lika is area whose habitats and habitat types are important for conservation of many endangered plant and animal species. Maintaining and improving current nature protection system of Lika and Croatia is important for protection of unique beauty of nature in Lika.