„Down syndrome is one of the most common genetic disorder caused by resence of all or part a third copy of chromosome 21. The human body is made up of approximately a trillion cells that mostly contain 46 chromosomes. Children born with Down syndrome (DS) have one chromosome extra (number 21) in each of their cells. (V.Čulić, S.Čulić, 2008). This disorder is significantly observed in all areas and prevents the physical and mental development of the child. People with Down syndrome (DS), with a specific face shape, are characterized by hypotonicity of the complete musculature, which can be clearly seen at an early age. Low muscle tone along with reduced strenght and endurance significantly aggravates mastering fundamental formes of movemant. Furthermore, those people at an early age get the characterization of joint hypermobility, primarily caused by longer ligament in the joint system, which is especially evident on the joints of the shoulders, hips and feet. Also, what is typical for children with DS is lack of muscle strenght which can be developed trough exercise as with any other person. (Piteti, Baynard, Agiovlasitis, 2013.) That is why the characteristics and importance of physical activity are a key role in the development and progress of children with DS. What are going to be results mostly depends on careful and appropriate selection of content. Physical activity is extremely important and indispesanble for people with DS. Since the researce was conduced during pandemic time of COVID-19, the aim of this study was to determine the impact of physical activity on the functional and psychomotor development of a child with DS based on a case study of a girl attending first grade of primary school Stanovi in Zadar before the emergence of measures adopted in accordance with COVID-19 were the child was included in a regular physical education program at school and in addition attended dance classes, to compare it with the time of pandemic when the child physical activity was reduced, regarding to absence of regular classes which includes physical education and absence of dance classes. The results of the research indicated that there are differences between the conditions before of the appearance COVID-19 pandemic measures and after the appearance of the measures. Although the differences are not large, they do exist, and are manifested in the motor abilities of flexibility, coordination, and repetitive strength in favor of the condition that existed before the advent of the measures. We can conclude that the effect of physical activity is extremely important for the entire psychomotor and social development of children with DS. That is why we must not ignore it but encourage it both in physical education classes and extracurricular activities.