Children are enrolled in special educational institutions due to severe developmental difficulties and their inability to follow the process of education in regular educational institutions. The main tasks of special educational institutions are to provide students with quality education tailored according to their interests and abilities and to include students in the social life of the community. In addition to educational work, special educational institutions offer their students rehabilitation work which, as well as educational work, is carried out according to individual plans and programs based on high pedagogical standards. This research presents the specifics of pedagogical work in the teaching process of children with disabilities in the Center for Education Juraj Bonači Sinj. The research was conceived as a case study that provided a quality and deep insight into the teaching processes of the Center. In addition to the analysis of pedagogical documentation, the main research method in this case study was a semi-structured interview. The educational work of teachers in four educational groups of the Center is presented and compared with the teaching process in regular educational institutions. The results of the research show that, unlike the teaching process in regular educational institutions, the approach to students is more individualized, the use of didactic materials is more frequent, as well as their production. Also, parental cooperation is necessary and more frequent, and the whole school day is adjusted exclusively to the student’s needs, interest and abilities.