The topic of the paper is Interreg program HR-BA-ME in the function of entrepreneurship development. Interreg is one of the programs implemented within the European Union. The reason for the analysis of Interreg and cross-border programs is that they were one of the tools of regional policy, and one of their goals was the networking of regions or local authorities sharing the border (networking of border states) of particularly underdeveloped regions, in order to reduce border and promoting socio-economic cohesion. In order to understand the goal and mode of operation of all programs by which the EU seeks to achieve goals, such as human resources development, rural development, environmental protection, urban development, upgrading education, agricultural development, energy conservation through various elements of energy efficiency, etc., it will be briefly described what the EU is, what programs it has and each program will be analized, and then the focus shifts to the Republic of Croatia and the development of small business then to the INTERREG program launched in 1989 as a tool to improve launched by European Interstate Cooperation. It will be analyzed how these projects stimulated the development of entrepreneurship in Croatia, and a cross-section of the state of the economy will be made with regard to the number of entrepreneurs in Croatia, and the launch and implementation of the Interreg program HR-BA-ME in the function of entrepreneurship development.