The process of Romanization differs from the original term "Romanization", which is burdened with the connotations of European colonialism and imperialism, and the discussion of this term is complex and intertwined within the study of Roman archaeology. In this paper, various approaches to the paradigm of Romanization will be studied and an attempt will be made to apply them to archaeological sources of ancient Issa. In order to achieve a more precise interpretation, the focus will be on material remains from the late Hellenistic period and the early Roman empire in Issa. In that period, we notice the most tangible changes affecting all spheres of the life of an Isean citizen conditioned by the change of power. Observing through the prism of administration, religion, urban projects, economy and funeral rituals, we'll be able to examine if Iseians follow global trends and what are the new adopted or adapated elements considered Roman and how they affected afore-mentioned aspects.