Bovine foot rot, an infectious disease with an acute course, localized in the interpalatal area of cattle, affects the skin of the interpalatal space and subcutaneous tissue. The disease manifests with progressive lameness, symmetrical swelling of the affected hoof and crown part of the skin, and the development of necrotic skin fissures accompanied by an unpleasant odor, peeling of the skin and exudation. The primary causative agent is the gramnegative anaerobe Fusobacterium necrophorum, an opportunistic bacterium of the beef cattle. In addition to the mentioned microbes, infection with Dichelobacter nodosus also favors the development of the disease, and in some studies, bacteria such as Prevotella intermedia and Porphyromonas levii have also been isolated. With the progression of the disease, i.e. the absence of adequate antimicrobial therapy, the animal is not using the affected leg, and the surrounding structures such as distal tendons and ligaments may become abscessed, which ultimately leads to the development of digital arthritis, tendovaginitis or osteomyelitis, and in the worst case, septicemia. The previously mentioned localized symptoms of this disease are also accompanied by systemic problems such as elevated temperature and loss of appetite, which directly leads to reduced conversion in beef cattle. It is necessary to start the therapy as early as possible, and the combination of local and systemic antimicrobial treatment generally leads to satisfactory results. Bearing in mind that the development of F. necrophorum favors the moist environment of the outlet, inadequate care of the hooves and the trauma of the interpalatal space, prevention is key with the maximum improvement of housing conditions to prevent the disease. Lameness as a result of foot rot is the cause of significant economic losses and a decrease in the well-being of beef cattle.