Honeybee (Apis mellifera) is considered one of the most favorable species of bees for modern way of beekeeping because of her good biological and producing characteristics. Nosemosis is a parasitic disease of adult honeybees, caused by microsporidia Nosema apis and Nosema ceranae. Nosemosis type C is a significantly pathogenic disease with chronic course and long incubation period, which usually passes asymptomatically or manifests by nonspecific symptoms like gradual weakening of honeybee colonies, enhanced loss of adult bees and decreased production of honey. Because of asymptomatic nature, significant pathogenic and prohibited use of antibiotics, nosemosis type C represents serious problem in modern beekeeping. Regarding this issues, the researches today are focused on determination of effectiveness of natural supstances in controlling and combating nosemosis. BPC 157 is a high stable protein, which is used without carrier, systematically and locally. The researchers on mammals showed that it considerably enhances healing of different matter. So, the aim of this research was to determine the effect of applying pentadecapeptide 157 as food supplement during autumn additional feeding on a number of N. ceranae spores, and with presumption about possible effect on healing micro damages of honeybee middle intestine.