Obesity is the factor, both, in humans and in animals, associated with many disease conditions resulting in a shortened life span. In carnivores, the obesity is the cause of numerous disorders, but in contrast to humans and horses, it doesn’t provoke the metabolic syndrome in them. Endocrine disorders in metabolic syndrome result in insulin resistance and type 2 diabetes. Certain types of adipokines from adipose tissue contribute to insulin resistance. In horses with metabolic syndrome, the insulin resistance is exacerbated by the condition of compensatory hyperinsulinemia. Cows’ adiposity is characterized by lipomobilisation syndrome in which exceptional mobilization of adipose tissue leads to fatty liver. To the fat syndrome in cows, they are often related ketosis, mastitis, metritis, hypocalcemia, inactive ovaries and ovarian cysts. Ketosis can cause cirrhosis of the liver, for which the animal is losing its good production properties and is eventually expelled from the production. In the treatment of metabolic syndrome in animals, it is applied, in addition to quality food, a restrictive diet and increased physical activity, also the medical therapy.