The liver is a compact organ of a reddish-brown color which is located beneath the diaphragm. It is the largest gland and also the biggest internal organ in a body. It has four lobes, four lobules and two processes. The gallbladder is located on the visceral surface. The liver’s function is extremely diverse; it produces bile that helps in digestion and removing waste products from blood, detoxicates some of the toxins and drugs and it has the largest metabolic and biochemical function in the organism. The liver also stores vitamins and produces almost every coagulation factor which promotes blood clot formation. A damaged liver has a great regeneration ability, however exceeding its capacity, the liver tissue starts developing fibrosis and might cause cirrhosis – the end stage liver disease. Hepatitis can be acute or chronic, depending on the traits and the duration of inzults(ovo nisam siguran, al nije inzults), as well as the defending mechanisms of the dog's liver. Clinical signs of hepatobiliary diseases are highly diverse and usually non-specific like anorexia, depression, vomiting and diarrhea, so just a clinical examination is not enough to make a diagnosis. Therefore, choosing a specific diagnostic method is necessary in further diagnostic processes. With a routine biochemistry panel screening, an increased activity of liver enzymes can be found, like ALT and AST or AP and GGT which are somewhat more specific for biliary diseases. In standard blood examination, a presence of hipoalbuminemia can be noticed, because the liver is the only source of albumin production in the organism. Furthermore, hyperbilirubinemia and jaundice development can lead to liver disease, but that is not always the case. Hence, further diagnostic procedures are needed. Besides stated, in routinely done blood examination, an elevated urea and cholesterol concentration can be observed, as well as reduced glucose concentration. A better insight into the liver’s function, bile excretion and enterohepatic circulation can be provided by measuring serum bile acid concentration. Radiographic evaluation, a part of diagnostic imaging, is used to complement the physical examination findings in a dog, and can help in the subjective evaluation of the size and liver position. Additionally, it provides information about potential presence of liver masses. For more detailed liver screening, including vascular and biliary liver structures, including parenchyma uniformity, it is recommended to perform ultrasonography. However, ultrasonography sensitivity for liver disease is not 100% 42 accurate, meaning that one can't exclude some diseases if they are not visible at that moment. The foundation for almost all objective diagnosis for liver diseases is biopsy. It can determine inflammation, neoplasia and parenchymal disease. In addition to this, we can use gallbladder aspiration. The veterinarian chooses the diagnostic methods based on equipment availability, the animal's condition and the financial status of the owner, all in order to get as accurate diagnostic results as possible and thus improving the wellbeing of a dog. liver, bile, diagnosis, blood examination, biopsy.