Scleroderma is a connective tissue disease of unknown etiology. We distinguish between localized and systemic scleroderma by type. Scleroderma is a disease that first manifests itself on the skin of the hands and face, and with the progression of the disease there is damage to internal organs. This autoimmune disease is characterized by symptoms such as skin tightening, decreased range of motion, Raynaud’s phenomenon, and soreness. Due to the large amounts of accumulated collagen, patients with scleroderma have a recognizable appearance "face like a mask." After diagnosing scleroderma begins the appropriate form of physiotherapy. Some of the physiotherapeutic interventions that can be applied in patients with scleroderma are: exercises to increase range of motion and mobility, phototherapy, manual lymphatic drainage and paraffin therapy. The objectives of this study are: to determine the impact of physical activity on the development of scleroderma, to determine the impact of physiotherapeutic agents on the treatment of scleroderma, to determine the impact of phototherapy on the progression of scleroderma, to determine whether manual techniques affect the development of scleroderma and to determine the importance of tests and measurements in the assessment and evaluation in patients with scleroderma.