Rheumatic or musculoskeletal diseases belong to large non-homogeneous group of diseases of the locomotor system, and the cause of their formation is usually unknown. The important facts are the changes of the skin in rheumatic patients because they are often diagnostic sign that should not be ignored, as they may be signs of many other diseases. Crohn's disease is a chronic inflammatory digestive system disease of unknown etiology, and usually affects the terminal ileum. Ulcerative colitis is a chronic idiopathic inflammatory bowel disease that affects the colon and extends continuously from rectum to the proximal. Nodose erythema is the most common form of acute paniculitis. It occurs acutely and is characterized by the sudden appearance of erythematous painful nodes and plaques dominantly localized on the extensor sides of the lower extremities. Sarcoidosis is a chronic inflammatory disease characterized by granuloma formation in many organs. Behcet's syndrome is a rare disorder that causes inflammation of the blood vessels (vasculitis) throughout the body, etiology is unknown. The main signs of the disease are oral, genital, ocular and skin lesions. Infectious arthritis is an inflammatory joint disease that triggers infectious agents, most commonly gram-positive and gram-negative microorganisms and spirochetes. Reactive arthritis is a disease characterized by a triad of arthritis, urethritis and conjunctivitis. Systemic sclerosis is a connective tissue disease that causes elastic fibers to collapse and collagen fibers build up in the skin and blood vessel walls that make the binder hard, inelastic, and rigid. Rheumatic fever seems to be a complication of a sore throat, nose, sinus, ear or tonsillopharyngitis. Infection is caused by group A streptococcus-beta hemolytic streptococcus. Paget's disease is a chronic bone disorder that usually results in enlarged, deformed bones due to excessive breakdown and bone formation. In addition to drug therapy, physiotherapy plays an important role in treatment. Patients are suffering from rheumatic diseases, and in parallel they have symptoms of various diseases that make their health condition even worse, therefore physiotherapy procedures should be adapted to the patient's capabilities. Patient education is an integral part of treatment.