The goal of this paper is to highlight the existing ecotourism offer of the Mura-Drava Regional Park and to outline the future activities and steps that local and regional self-government plans need to undertake for the further development of ecotourism. The purpose of the work is to point to a large number of unused potentials of the mentioned area that can be valorized and used for tourist purposes on the example of some protected natural areas in the Republic of Croatia. The beginning of the paper refers to the general characteristics of ecotourism, such as its principles and dimensions that represent the essence of the overall concept. Ecotouristic trends and movements are highlighted by the new motives for travel of a modern tourist. The chapter continues on ecotourism in protected areas of nature, which is linked to the development of such form of tourism. In the Republic of Croatia, most of these areas are intended for tourist activities and recreation, although there are a large number of protected areas that are neglected and unused for tourist purposes. One of the most important reasons for such a situation is over-orientation of coastal vacation tourism. The Mura-Drava Regional Park, as one of the tourisms most unused and exploited areas, with its natural, cultural, historical and traditional features presents great potential for development of ecotourism. It's located in five Croatian counties which have specific demographic characteristics, that is, the coexistence of man and nature. The current ecotourism development in the Park area is relatively weak and is most developed in the area of Međimurje County. Further development of ecotourism in this area should, besides nature, culture, and history, be based on the specifics of the local population and their lifestyle and the recognizable image of the protected area.