Many years of work in the hotel and knowledge acquired at the Polytechnic of Karlovac has changed the author's view on the issue of security and protection from fire and explosion and in particular the approach to this problem in hotels. Therefore, this final paper attempts to show that care about customer means not only providing quality catering services, which defines the degree of meeting customer expectations and requirements, but also the care of his overall safety and security during his stay at the hotel. This is why it is of great importance constantly to update professional evaluation of the danger of all the types of adverse events that in certain situations could jeopardize the safety and health of hotel guests and employees. This paper attempts to present the main features of all those meaningful usual fire and explosion hazards that may exist and those that can extraordinarily appear in hotels, on which the management responsible for the overall safety and security, with the understanding and management support of general manager or owner of the hotel, should constantly pay attention. This means consistently taking all the Law on Fire Protection and the relevant secondary legislation defined measures and activities in order to make hotel more secure residence, and also at the same time from the point of view of safety and protection from fire and explosions. This can be achieved only by investing in construction and technical security of the hotel, appropriate safety education and training of hotel staff, regular preventive examinations, regular analysis and evaluation of danger and threat from fire and explosion, adjusting the plan of the safety data maintenance and urgent treatment in the event of fire or risk of explosion, as well occasional organizing expert guided exercises of control evacuation and rescue of guests and employees, in order to avoid or at least significantly mitigate the possible consequences in case of fire or explosion. For a better insight into possible fire and explosion hazards in the hotels and in the possible dire consequences of such events here are presented three significant example cases of fire in hotels. With these examples, we tried to point out the typical causes and possible consequences of a fire in hotels. They show how human casualties and resulting damage can be extremely large.