Over the last three decades, the County of Istria, recognizing the importance of entrepreneurship development and thanks to numerous and generous investments in the Istrian economy and entrepreneurship, has achieved enviable economic indicators and reached the very top of competitiveness and economic strength over other Croatian counties. The subject of this paper are the possibilities of entrepreneurship development in the County of Istria with prognostic perspectives for its development. The aim of the research is to present the current development of entrepreneurship in the County of Istria, opportunities and potentials that it has to improve this development, as well as to present future prospects for the development of entrepreneurship in the County of Istria, analyzing its development strategies, programs and competitiveness. The purpose of the research is to point out the importance of future perspectives for the development of entrepreneurship for the County of Istria and how much its progressive development can contribute to the improvement of the economy of the County of Istria. The results of the research showed that, developing strategies of development programs for the promotion and encouragement of entrepreneurship, the Istrian County began to develop exponentially, where the Istrian economy quickly reached one of the highest rates of economic growth in the country. The County of Istria has achieved great success in entrepreneurship, especially in the sectors of tourism, agriculture, fisheries and trade. These sectors have excellent development potential in Istria primarily due to the favorable geographical and climatic position of Istria, rich natural and cultural resources, as well as the proximity of the sea and many developed cities, which are small in structure but have shown significant success in entrepreneurship.