Vine vine (lat. Vitis vinifera L.) is a herbaceous plant from the Vitaceae family. It is believed that along with barley, olive and wheat vines is one of the oldest culture crops in the world. Croatia is due to climate, relief and many other factors suitable for the cultivation of high quality grape varieties, but the same conditions also favor the development of various diseases and impair that affect the health of the plant. Grape vine attacks a number of diseases, and the most dangerous are: plasmopara viticola, powdery mildew, and more frequent black spots, red fire disease of grapevine, agrobacterium tumefacines, Botrytis cinerea, grapevine leaf roll virus, infectious degeneration, grapevine yellows. The most commonly used to control the disease are chemical agents because of their high efficacy, but it should be noted that every well-made agrotechnical measure helps to fight the disease. The aim of the final work is to show the most significant diseases of vine vine, way of growing and plant protection in the vineyard on Family farm Lalić.