The holistic approach in occupational therapy encourages the childs complete development in a way that a child with difficulties in development, orientation and social interaction can learn through various programs and methods of stimulation. With these programs and methods we can expect improvements in the childs functional abilities in all life aspects. Focusing on the childs undestanding and sense of self and its enviroment, the child learn to control its behaviour, to be independent aswell as learn to understand and comunicate with its surroundings. All activities are accomplished with the purpose of supporting the child to ensure the progress of its development, raise the childs and its familys confidence and encourage social inclusion of the child aswell as its family. In this work i have followed programs and development of a child with a diagnosis of tuberous sclerosis with accompanied problems in behaviour and development, epilepsy and some signs of autism. The purpose of this work is to show what methods and programs can be used to help and work with a child with similar simptoms and the importance of team work and the holistic approach. This work reviews various methods such as the Bowen method, neurofeedback, sensory integration, educational-rehabilitational approach and occupational therapy. It covers exercises of motoric and social development, stimulating the sensoric integration, exercises to stimulate speech and language, encouraging functional learning and the support of the family.