Flexographic printing technique is a technology that has been steadily growing its presence in the current market. Rapid development and modernization have led to an increased demand for higher quality reproduction. Consequently, the research presented in this paper focuses on the examination of graphic products’ quality. Descriptions of graphic reproductions were formulated on the basis of objective (measurable and visual) analysis of reproduction quality. Additionally, several qualitative parameters were examined in the process of objective analysis of reproduction quality, whereby some of these qualitative parameters were divided into subgroups. The selection of samples was defined in line with the modern methods for labeling. Examined samples were printed in real production on two non-absorbent substrates. The process involved the use of solvent-based inks and environmentally friendly inks also known as UV curable inks. The results of research indicated the necessity to use an increased number of qualitative parameters for describing the quality of reproductions. Samples obtained by way of applying environmentally friendly inks have a more adequate value of qualitative parameters compared to reproductions obtained with the use of solvent-based inks. There is a significant discrepancy between the size of dot gain in reproductions made by environmentally friendly inks and the recommended dot gain set forth in the ISO standards. On the other hand, the reproductions made with solvent-based inks are of a similar size. According to that, a conclusion has been drawn that the ISO standards, which are currently in force, have to be supplemented by way of considering the existence of contemporary inks. The research established which qualitative parameters are used as the criterion for defining a better assessment of the overall visual quality of a reproduction as well as the reproduction of a gold color imitation. Recommendations were made on new values for the total area coverage on a substrate and on control stripe values for defining gray balance. A method for the most accurate assessment of trapping in flexographic printing technique has been defined as well. Interlinking the results of objective analysis (measurable and visual) will render possible the definition of the criterion for reproduction quality. The criterion for reproduction quality represents a proposal for defining and predicting the overall quality of reproductions. Based on a logistic regression analysis, the criterion for reproduction quality has been created as a probability function affected by the selection of qualitative parameters when the reproduction is rated as a high quality reproduction.