prikaz prve stranice dokumenta Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumour necrosis factor
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Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumour necrosis factor
Journal of General Virology, 75 (1994); 101-110. urn:nbn:hr:184:602109
Lučin, Pero; Jonjić, Stipan; Messerle, Martin; Polić, Bojan; Hengel, Hartmut; Koszinowski, Ulrich H.

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

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Lučin, P., Jonjić, S., Messerle, M., Polić, B., Hengel, H. i Koszinowski, U. H. (1994). Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumour necrosis factor. Journal of General Virology, 75., 101-110. Preuzeto s https://urn.nsk.hr/urn:nbn:hr:184:602109

Lučin, Pero, et al. "Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumour necrosis factor." Journal of General Virology, vol. 75, 1994, str. 101-110. https://urn.nsk.hr/urn:nbn:hr:184:602109

Lučin, Pero, Stipan Jonjić, Martin Messerle, Bojan Polić, Hartmut Hengel i Ulrich H. Koszinowski. "Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumour necrosis factor." Journal of General Virology 75 (1994): 101-110. https://urn.nsk.hr/urn:nbn:hr:184:602109

Lučin, P., et al. (1994) 'Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumour necrosis factor', Journal of General Virology, 75, str. 101-110. Preuzeto s: https://urn.nsk.hr/urn:nbn:hr:184:602109 (Datum pristupa: 07.11.2024.)

Lučin P, Jonjić S, Messerle M, Polić B, Hengel H, Koszinowski UH. Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumour necrosis factor. Journal of General Virology [Internet]. 1994. [pristupljeno 07.11.2024.];75:101-110. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:602109

P. Lučin, S. Jonjić, M. Messerle, B. Polić, H. Hengel i U. H. Koszinowski, "Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumour necrosis factor", Journal of General Virology, vol. 75, str. 101-110, 1994. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:602109. [Citirano: 07.11.2024.]

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Naslov (engleski)Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumour necrosis factor
AutorPero Lučin
AutorStipan Jonjić
AutorMartin Messerle
AutorBojan Polić
AutorHartmut Hengel
AutorUlrich H. Koszinowski
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Katedra za fiziologiju, imunologiju i patofiziologiju)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
We have shown previously that the antiviral function of CD4 + T lymphocytes against murine cytomegalovirus (MCMV) is associated with the release of interferon-?, (IFN-),). We now demonstrate that IFN-?, and tumour necrosis factor alpha (TNF-~<) display synergism in their antiviral activity. As little as 2 ng/ml of IFN-), and TNF-~ reduced the virus yield by about three orders of magnitude. There was no effect on immediate early (IE) and early (E) gene expression as far as the candidate genes IE1, E1 and those encoding the major DNAbinding protein and the DNA polymerase were concemed. Late gene transcription, assayed by the candidate genes encoding glycoprotein B and the MCMV homologue of ICP 18.5, was blocked and MCMV DNA replication was found to be reduced but not halted. The most prominent finding of the cytokine effect, seen by electron microscopy, was an alteration of nucleocapsid formation. Altogether, the synergism is multifaceted and acts at more than one stage during viral morphogenesis. Because the cytokines clearly do not act at an early stage of infection we conclude that the mode of cytokine activity differs between alpha- and betaherpesviruses.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaJournal of General Virology
Brojčani podacivol. 75, str. 101-110
p-ISSN0022-1317
e-ISSN1465-2099
URN:NBNurn:nbn:hr:184:602109
Datum objave publikacije1994
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje 4.0 međunarodna (CC BY 4.0)
Datum i vrijeme pohrane2019-11-19 16:21:40