prikaz prve stranice dokumenta Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR
  Preuzmi
PDF 1.28 MB
Znanstveni rad - Izvorni znanstveni rad
Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR
European Journal of Immunology, 43 (2013), 8; 2138-2150. https://doi.org/10.1002/eji.201243072
Stanietsky, Noa; Roviš, Tihana Lenac; Glasner, Ariella; Seidel, Einat; Tsukerman, Pinchas; Yamin, Rachel; Enk, Jonatan; Jonjić, Stipan; Mandelboim, Ofer

Institucijski repozitorij: Repozitorij Medicinskog fakulteta u Rijeci

Citirajte ovaj rad

Stanietsky, N., Roviš, T. L., Glasner, A., Seidel, E., Tsukerman, P., Yamin, R. ... Mandelboim, O. (2013). Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR. European Journal of Immunology, 43. (8), 2138-2150. doi: 10.1002/eji.201243072

Stanietsky, Noa, et al. "Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR." European Journal of Immunology, vol. 43, br. 8, 2013, str. 2138-2150. https://doi.org/10.1002/eji.201243072

Stanietsky, Noa, Tihana Lenac Roviš, Ariella Glasner, Einat Seidel, Pinchas Tsukerman, Rachel Yamin, Jonatan Enk, Stipan Jonjić i Ofer Mandelboim. "Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR." European Journal of Immunology 43, br. 8 (2013): 2138-2150. https://doi.org/10.1002/eji.201243072

Stanietsky, N., et al. (2013) 'Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR', European Journal of Immunology, 43(8), str. 2138-2150. doi: 10.1002/eji.201243072

Stanietsky N, Roviš TL, Glasner A, Seidel E, Tsukerman P, Yamin R, i sur.. Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR. European Journal of Immunology [Internet]. 08.2013. [pristupljeno 13.05.2024.];43(8):2138-2150. doi: 10.1002/eji.201243072

N. Stanietsky, et al., "Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR", European Journal of Immunology, vol. 43, br. 8, str. 2138-2150, Kolovoz 2013. [Online]. Dostupno na: https://urn.nsk.hr/urn:nbn:hr:184:164597. [Citirano: 13.05.2024.]

Za citiranje koristite ovu mrežnu adresu: https://urn.nsk.hr/urn:nbn:hr:184:164597
Podaci o radu
Naslov (engleski)Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR
AutorNoa Stanietsky
AutorTihana Lenac Roviš
AutorAriella Glasner
AutorEinat Seidel
AutorPinchas Tsukerman
AutorRachel Yamin
AutorJonatan Enk
AutorStipan Jonjić
AutorOfer Mandelboim
Autorova ustanovaSveučilište u Rijeci
Medicinski fakultet
(Centar za proteomiku)
Znanstveno / umjetničko
područje, polje i grana		BIOMEDICINA I ZDRAVSTVO
Temeljne medicinske znanosti
Sažetak (engleski)
The activity of natural killer (NK) cells is controlled by a balance of signals derived from inhibitory and activating receptors. TIGIT is a novel inhibitory receptor, recently shown in humans to interact with two ligands: PVR and Nectin2 and to inhibit human NK‐cell cytotoxicity. Whether mouse TIGIT (mTIGIT) inhibits mouse NK‐cell cytotoxicity is unknown. Here we show that mTIGIT is expressed by mouse NK cells and interacts with mouse PVR. Using mouse and human Ig fusion proteins we show that while the human TIGIT (hTIGIT) cross‐reacts with mouse PVR (mPVR), the binding of mTIGIT is restricted to mPVR. We further demonstrate using surface plasmon resonance (SPR) and staining with Ig fusion proteins that mTIGIT binds to mPVR with higher affinity than the co‐stimulatory PVR‐binding receptor mouse DNAM1 (mDNAM1). Functionally, we show that triggering of mTIGIT leads to the inhibition of NK‐cell cytotoxicity, that IFN‐γ secretion is enhanced when mTIGIT is blocked and that the TIGIT‐mediated inhibition is dominant over the signals delivered by the PVR‐binding co‐stimulatory receptors. Additionally, we identify the inhibitory motif responsible for mTIGIT inhibition. In conclusion, we show that TIGIT is a powerful inhibitory receptor for mouse NK cells.
Ključne riječi (engleski)
Jezikengleski
Vrsta publikacijeZnanstveni rad - Izvorni znanstveni rad
Status objaveObjavljen
Vrsta recenzijeRecenziran - međunarodna recenzija
Verzija publikacijeObjavljena verzija rada (izdavačev PDF)
Naslov časopisaEuropean Journal of Immunology
Brojčani podacivol. 43, br. 8, str. 2138-2150
p-ISSN0014-2980
DOIhttps://doi.org/10.1002/eji.201243072
URN:NBNurn:nbn:hr:184:164597
Datum objave publikacije2013-08
ProjektŠifra: 320473
Naziv (hrvatski): Recognition of bacteria by NK cells
Kratica: BACNK
Pravna nadležnost: eu
Financijer: EC
Linija financiranja: FP7
ProjektŠifra: 1R01AI083201-01
Naziv (hrvatski): Viral evasion of NK cells
Pravna nadležnost: Sjedinjene Američke Države
Financijer: NIH
URL dokumentahttp://doi.wiley.com/10.1002/eji.201243072
Vrsta resursaTekst
Prava pristupaOtvoreni pristup
Uvjeti korištenjaIkona licence Imenovanje-Nekomercijalno-Dijeli pod istim uvjetima 4.0 međunarodna (CC BY-NC-SA 4.0)
Datum i vrijeme pohrane2020-04-19 13:39:47